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Description

Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine

qu trnh lo ha s tng tc v khin c th d b tn thng hn khi c cc tc nhn gy bnh tn cng

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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig