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Another example is a study that reported Curcumin Encapsulated Lipidic Nanoconstructs (CLEN) achieving an approximately 1.4-million-fold increase in aqueous solubility and about a 70-fold improvement in oral bioavailability compared to free curcumin (40)

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According to the American College of Rheumatology, the effects of scleroderma vary widely and range from minor to life-threatening, depending on how widespread the disease is and which parts of the body are affected. Types of Scleroderma Localized scleroderma Localized scleroderma generally is limited to the skin, although it can affect the bones and joints

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