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In clinical trials at the 12 mg dose, researchers documented nausea in 28% of participants, diarrhea in 23%, constipation in 17%, and vomiting in 12%

Notably, CD276 was expressed on both newly formed and pre-existing vessels present inside tumours but not in normal vessels outside the neoplastic mass and not during physiological angiogenesis (e.g., regenerating liver tissue) [44]

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