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M1 microglia release neurotoxic and inflammatory factors such as IL-6, IL-1, and TNF-, contributing to neuronal damage and death, while M2 microglia secrete neurotrophic factors including BDNF, IL-4, and IL-10, fostering neuronal growth and protection (51)

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Nasal or Sinus cancers Very rarely, cancers in the nose or sinus can cause a change in smell, reduced or loss of smell

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Andrew Hyland with Roswell Park Comprehensive Cancer Institute says reduced-nicotine cigarettes could be helpful in breaking the habit for smokers

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