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Haem assimilation was first targeted with the analogue gallium-protoporphyrin IX (GaPP), a bactericidal metalloporphyrin that uses existing haem uptake machinery to gain entry to the bacterial cell (Stojiljkovic et al., 1999)

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Trimethylamine N Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

While low mTORC1 activity supported localization near tumor cells, hyperactivation of mTORC1 via loss of the negative regulator TSC1 shifted their localization to perivascular regions

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