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have shown that IGF-1 intervention could upregulate myostatin expression through the phosphatidylinositol 3-kinase pathway ( 2+ -dependent nuclear factor of activated T cells (NFAT) transcription factor to bind to the MSTN promoter through the phospholipase C gamma (PLC)/inositol 1,4,5-triphosphate (IP3) signaling pathways, thereby regulating the transcription of MSTN ( In addition, a CCAAT box and a C/EBP-binding element (CBE) in the MSTN promoter are the two potential C/EBP-binding sequences ( 3 MSTN in regulating cell metabolism 3.1 Mitochondria Mitochondria are energy factories in cells, synthesizing large amounts of ATP to provide energy for the bodys activities ( Ploquin et al

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[Google Scholar] [95].Hyndman D, Flynn TG, Lever G, Burrell R, Protein immobilization to alumina supports: I