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In the end, ferroptosis-induced inflammation would trigger or even aggravate development of CCVDs

To counter these threats, cells have evolved molecular chaperones that mitigate the toxic effects of such proteins by preferentially binding to exposed hydrophobic regions, thereby facilitating their refolding or targeting them for degradation 62,94

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10.1016/j.cell.2018.10.001 47 KalamkarS.AcharyaJ.Kolappurath MadathilA.GajjarV.DivateU.Karandikar-IyerS.et al (2022)