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Description

Other gene mutations, such as MTHFR A1298C, chronic bacterial infections, and aluminum, can also lead to low BH4 levels

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In the course of the experiments, tert-butyl hydroperoxide (TBHP) was used to induce oxidative stress in annulus fibrosus cells (AFCs) and nucleus pulposus cells (NPCs)

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This limitation does not undermine the studys value in identifying a novel regulatory axis but highlights the need for follow-up experiments to strengthen mechanistic claims

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Benham AJ, Gallegos D, Hanna KL et al

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Spine (Phila Pa 1976) 24 (23), 24192425

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Med 79, 207214 (2022)

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