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They mapped out how each amino acid position influenced different properties: positions 3 and 7 might control binding affinity, while positions 5 and 12 determined membrane permeability, and positions 9 and 15 governed metabolic stability

study (1998) compared four topical treatments on human skin over one month, with immunohistological analysis of skin biopsies (actual tissue samples examined under a microscope)

Science 310 (5751), 11931196

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