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(2) Specific binding of low-affinity ligands to receptors usually requires high or even supersaturated concentrations to ensure effective recognition

We found increased NLRP3 immunolabeling in the RPE at sites of CNV lesion formation and increased expression of NLRP3 and of proangiogenic IL1 that is activated by the NLRP3 inflammasome in the RPE/choroids of VEGFA hyper mice, while IL18 expression was not increased (Fig 7AC)

In addition, the efficacy of probiotics were evaluated based on clinical data, which were collected and analyzed differently

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