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The creation of thousands of tiny holes dramatically increases the ability of active ingredients to pass through the stratum corneum (the thin layer of skin composed of already dead skin cells that functions as a barrier) and reach the epidermis where the active ingredients are needed

Acivicin, which diminishes the availability of glutathione-derived glutamate, decreased average mEPSC frequency significantly, though not to the same extent as MeAIB (Fig