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While the exact cause of these mutations is not always clear, several risk factors are associated with oral cancer: Tobacco Use: Smoking cigarettes, cigars, or pipes, as well as using smokeless tobacco products like chewing tobacco, is a leading cause of oral cancer

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Look closely: Krusty and Homer have the exact same build and facial features Krusty is literally just Homer with clown makeup, and early on, Groening toyed with making the clown Homer's alter ego

She lets him know that he was picked up by a ghost driver, and that ten years earlier, at the very same intersection where he was picked up, Big Joe swerved to avoid hitting a school bus full of children