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Patent and Trademark Office (USPTO)

Together, these findings indicate that reactive nitrogen species promote TTR crosslinking through reversible thiol activation, whereas strong oxidants divert cysteine chemistry toward stable overoxidized states that suppress disulfide-mediated conversion

Therefore, if flash glucose monitoring is used for screening for prediabetes, individuals with greater glucose variability may have a higher incidence of neuropathy and retinopathy due to factors such as increased oxidative stress, advanced glycation end products, and inflammatory cytokine generation

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