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in Amino Acid BiosynthesisPathway, Regulation and Metabolic Engineering (ed

doi: 10.1016/j.jprot.2013.06.005 78 YadavS

Furthermore, oxidative stress is caused by free radicals or oxidant productions, including lipid peroxidation, protein modification, and DNA damage, and results in cellular degeneration and neurodegeneration from damage to macromolecules [36,107]

11,78 Moreover, suppressing either component of system Xc induces ferroptosis by disturbing cystine uptake, then limiting GSH synthesis

These reactions often act to detoxify drugs (although in some cases the intermediates in drug metabolism may cause toxic effects)

Psychiatry 47 , 351354 (2000)