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iNOS is activated during inflammatory responses or hypoxia and produces large amounts of NO, which can lead to oxidative stress if not properly controlled ( In the bloodstream, NO is rapidly captured by hemoglobin, forming nitrosyl-hemoglobin (HbNO) ( 2.1.1 NO enhances erythrocyte deformability Erythrocyte deformability, the capacity of red blood cells to alter shape as they traverse narrow capillaries, is vital for effective oxygen delivery

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In the rat, doses at the 120 mg/kg level, in the toxic range for the adult animal, were associated with an increase in embryo resorption at the time of implantation

Curcumin is a class IV Biopharmaceutics Classification System molecule with low solubility ( 005)

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