glutathione low elevated ferritin Injectable A fistful of iron: ferritin

A fistful of iron: ferritin as a vulnerability point of the brain cancers Cell Death & Disease Hyperferritinemia and inflammation PMC Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation. Superoxide dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically occurring Cu(I)glutathione complex ScienceDirect Glutathione scavenging natural derived ferroptotic nano amplifiers strengthen tumor therapy through aggravating iron overload and lipid peroxidation ScienceDirect HyperferritinemiaA Clinical Overview

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