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Specifically, SIRT3 deacetylates and inhibits aldehyde dehydrogenase 2, which prevents the conversion of acetaldehyde to acetate, potentially leading to acetaldehyde toxicity 183

However, reported benefits are not uniform across all trials or populations, and effect sizes are often modest, highly strain-specific, and influenced by background diet and host factors, which complicates broad generalization of these findings (13)

Cellulite improvement, if any, should be described as cosmetic and variable rather than permanent fat removal

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