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doi: 10.1038/s41580-020-0218-z 240 TepestR.VogeleyK.ViebahnB.Schneider-AxmannT.HonerW

MOTS-C activates AMPK for mitochondrial biogenesis and translocates to the nucleus under stress for direct metabolic gene regulation

Its structure is similar to that of the LDL particle

Unlike genetic mutations, which alter the DNA sequence, epigenetic changes impact chromatin structure and gene expression without modifying the DNA itself (Schulz 2023)