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Traditionally, the high GSH content in lens is believed to protect free thiols, which allows the structural integrity and/or proper biological functioning of various enzymes to be maintained 28

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11 Transcription factors are a class of protein which bind to DNA and induce the expression of particular genes, in the case of Nrf2, the pathway stimulates the production of potent antioxidants such as: NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTs), and many others, as shown in the table below

doi: 10.1038/s41571-023-00782-x 322 Rodrguez-RuizMERodrguezIMayorgaLLabianoTBarbesBEtxeberriaIet al

Decreased secretion of gastric intrinsic factor, the protein required for vitamin B12 absorption, may further decrease levels of this vitamin

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