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1 Introduction Parkinsons disease (PD) is a progressive neurodegenerative condition defined by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) that causes a variety of motor and non-motor symptoms ( 14 bacteria, play crucial role in sustaining host health and affecting physiological systems such as the central nervous system (CNS)

A right angle (90) suggests no correlation between the two variables

Their broad substrate range, including drugs and xenobiotics, and their high expression levels at the BBB, contribute a major part to CNS pharmacoresistance [75]

Capsaicin (CAP), a natural active ingredient in Capsicum annuum L

When Stable Schizophrenia was entered as a predictor, the R 2 of the model was 0.07, F (1, 71) = 5.332, p = 0.024, a small effect size, f 2 = 0.08

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