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Disclosure of interest: No conflict of interest E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.02 - GENETICS, OMICS AND BIOMARKERS P2577 - ESOC25-782 LARGE ARTERY ATHEROSCLEROTIC STROKE RELATED SNP VARIANTS ASSOCIATED WITH STROKE RISK FACTORS AND MECHANISMS IN SYMPTOMATIC INTRACRANIAL ATHEROSCLEROSIS Yue Gu 1 , Yifu Wang 2 , Qiaoshu Wang 2 , Xinyi Leng 1 1 Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, Hong Kong, 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Background and Aims: Previous studies have identified numerous risk loci for large artery atherosclerotic stroke (LAAS)

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Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine

Here, we investigated the mechanisms underlying the neuroprotective effect of neuronal stimulation during hypoxia observed in the human in vitro model of the ischemic penumbra previously published by us 18

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