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In the hypoxic environment, the expression of factors such as HIF1a is increased, which reduces sensitivity to chemotherapeutic agents by regulating gene expression to bring LSCs into a resting state (110)

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NAMPT-driven M2 polarization of tumor-associated macrophages leads to an immunosuppressive microenvironment in colorectal cancer

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In a bit upon deep inquiry, it was apparent that shed had a tumultuous upbringing with with lots of trauma, and interrupted bonds with the parents, their parents got divorced when she was three