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The activation of T helper (Th) cells including Th1, Th17, and Th22 cells trigger the inflammatory process of psoriasis and upregulate an array of proinflammatory cytokines [10], among, Th17 cells are the primary source of IL-22, which principally targets keratinocytes and orchestrates its effect through the activation of mitogen activated protein kinases (MAPKs) and signal transducer and activator of transcription 3 (STAT3) [11]

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COQ6 deficiency (OMIM #614650) Human Coenzyme Q10 monooxygenase 6 (COQ6) is a flavoprotein involved in the biosynthesis of Coenzyme Q10 which operates as a redox carrier by transferring electrons from respiratory chain Complexes I and II to Complex III

In high-transmission areas, malaria is one of the most common indications for blood transfusion, yet transfusion thresholds in severe malaria management remain uncertain ( Classical theories attribute malarial anemia to three primary mechanisms: direct parasite lysis of infected red blood cells (RBCs)