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(May 2015)

12,13 However, a critical gap remains in the systematic translation of these metabolic-epigenetic mechanisms into clinical interventions

Huntingtons Disease (HD)Iron, Mitochondria, and Striatal Neurodegeneration HD is an inherited neurodegenerative disorder marked by progressive loss of medium spiny neurons in the striatum (caudate and putamen), leading to motor dysfunction (chorea) and cognitive decline [239]

Lactobacillus casei probiotics increased the transport of drugs like -lactam antibiotics, and angiotensin-converting enzyme inhibitors (ACE inhibitors) by escalating the activity of the oligopeptide transporter hPEPT1 in the small intestine [23]

Procedure Peptides can be administered topically, orally, or through injections

Liquid-chromatography-inductively coupled plasma mass-spectrometry (LC-ICP-MS) and liquid-chromatography-electrospray ionization mass-spectrometry (LC-ESI-MS) enable direct detection of multiple metal-ligand complexes in vitro and in vivo , however, the technical difficulty of analyzing the intact complex remains the bottleneck [26]