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Even when used at low dose, APAP causes the impairment of mitochondrial respiratory chain, decreasing ATP reservoir and promoting reactive oxygen species accumulation 3

While genetic screening identified SMS and not specifically spermine, the control of both SPD and spermine by SMS may play a role in both immunosuppression and cancer aggressiveness

In addition, research shows it can enhance cognitive performance, including attention and task switching, and its been shown to boost energy levels

Liang H, Yoo SE, Na R, Walter CA, Richardson A, Ran Q

In 2020, there were 19.3 million new cases of cancer and 10 million cancer-associated deaths worldwide, and it was estimated that ~1.8 million of these individuals died of lung cancer (1)

Philippi H, Sommerfeld V, Windisch W, Olukosi OA, Monteiro A, Rodehutscord M