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When your brain perceives a threat, the hypothalamus releases CRH, which signals the pituitary to release ACTH, which tells the adrenal glands to produce cortisol

Not only does this cocktail of catecholamines have a vast effect on our mood and focus, but also the high density of cold receptors in our skin is sending an overwhelming number of electrical impulses from peripheral nerve endings to the brain

They're a helper, not a replacement for a healthy lifestyle

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Among these, liraglutide in the LEADER study, semaglutide in the SUSTAIN-6, albiglutide in the Harmony Outcomes, dulaglutide in the REWIND, and efpeglenatide in the AMPLITUDE-O exhibited significant beneficial effects on 3-point major adverse cardiac events (3P-MACE: death from CV disease, non-fatal myocardial infarction, and non-fatal stroke), the primary end point of each study, compared to the placebo group, respectively

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