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Serial FFPE sections of ICC cancer tissues were used for immunohistological examination and immunostained for CD4, CD20, CD8 and marker molecules reported to be associated with killer T cell activation or exhaustion

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Its delayed inhibitory effect on cellular function and high accumulation in lysosomes are frequently accompanied by disruption of protein and intracellular lipid transport, modulation of surface receptor expression, altered macrophage phenotype, and impaired autophagy (213)

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At 12 months, those in the vitamin D group had significantly greater improvements in overall cognitive function, as measured with a variety of tests assessing memory, attention, and processing