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The Institute of Medicine states no adverse effects have been associated with excess vitamin B12 intake from food and supplements in healthy individuals. [1] However, it is important not to start a high-dosage supplement of any kind without first checking with your doctor

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It must come from the diet or from other forms of supplementation

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The primers used in the cloning are listed in Supplementary Table 5

I use it both morning and night, so it runs out relatively quickly, but I like the effect so much that I'm ordering more