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Study selection, data extraction, and quality assessment Three authors (Jun S, Park H, and Kim UJ) decided if studies should be included based on the inclusion and exclusion criteria

This is standard for most manufactures of products

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These include: increased risk of oral cancer gum disease stained teeth bad breath (halitosis/oral malodour) tooth loss loss of taste and smell reduced blood supply to the mouth increased build-up of plaque biofilm and tartar on your teeth delayed healing following tooth extraction and other surgery in the mouth Current evidence indicates tobacco and alcohol together significantly increase the risk of mouth and throat cancers compared with either alcohol or tobacco use alone

For more detail on equivalence models and worked examples, see this nicotine equivalence guide

KCRHA also expanded the number of hub sites and added sites in locations recommended by community feedback, leading to more completed surveys