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In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

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[6] [8] Estradiol cypionate is contraindicated during pregnancy because exogenous estrogen has no therapeutic role in gestation and in utero exposure could theoretically disturb fetal endocrine development or contribute to structural anomalies, although robust human teratogenicity data are limited