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doi: 10.1074/jbc.M501931200 129 MakishimaMOkamotoAYRepaJJTuHLearnedRMLukAet al

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doi: 10.1097/00002030-199607000-00005 16 Sandoval-MontesCSantos-ArgumedoL

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An initial decrease and subsequent increase in Itch/AIP4 transcription in p53 wt and p53 null melanoma cells were mirrored by changes in Itch/AIP4 levels in p53 wt and p53 null in melanoma cells, suggesting that they were in response to the p28-induced increase in TAp63 and Np63

This further supported its use in adjuvant chemotherapy and raided the scientific interest in finding new analogues with anti-estrogenic activity and no estrogenic effects and most important with potent PGS inhibitory actions [15]