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Due to TJ and adhesive junction proteins strict regulation of the paracellular paths between endothelial cells, larger and polar molecules cannot pass through the BBB

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

The leftover material, or oleoresin, is then dissolved in methanol and analyzed using HPLC, as described by Yadav et al

It comes as a freeze-dried powder, called a lyophilized powder, that a lab dissolves before any study

At pH more than 7, it is unstable and shifts to the enol form, an electron donor that contributes to its antioxidant effects (79, 80)