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This not only conforms to the TCM cognition that "the spleen is the acquired foundation of life and the spleen, intestine and kidney are interconnected", but also compensates for the limitation of single-target Western medicines, realizing systematic regulation of complex pathogenesis and pathological networks

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de The Nat Cell Biol 10:547555 Wang ZG, Rivi R, Delva L, Konig A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP, Pandolfi (1998) Blood 92:14971504 Kozono S, Lin Y-M, Seo H-S, Pinch B, Lian X, Qiu C, Herbert MK, Chen C-H, Tan L, Gao ZJ, Massefski W, Doctor ZM, Jackson BP, Chen Y, Dhe-Paganon S, Zhou (2018) Nat Comm 9:3069 Kamynina E, Lachenauer ER, DiRisio AC, Liebenthal RP, Field MS, Stover PJ (2017) Proc Natl Acad Sci USA 114:E2319E2326 Hajj HE, Dassouki Z, Berthier C, Raffoux E, Ades L, Legrand O, Hleihel R, Sahin U, Tawil N, Salameh A, Zibara K, Darwiche N, Mohty M, Dombret H, Fenaux P (2015) H