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Peptide vaccines have been studied in combination with chemotherapy agents and drugs not intended to treat cancer, with promising results

The first line of defence is the plant cell wall and cuticular barrier, which not only provides a protective shield against physical damage by animals, insects, abiotic stresses (e.g., freeze-thawing) and bacterial and fungal pathogens that is not simply passive but transmits danger signals within the plant as immunogenic factors

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183 A mitochondria-targeting antioxidant can reduce the production of neutrophil mtROS and result in a decrease in NETosis

The rapid generation of O 2 and H 2 O 2 may mediate a further increase in cytosolic Ca 2+ [41] so elevating glucose metabolism via activation of specific Ca 2+ -sensitive metabolic enzymes (especially those located in the mitochondria), which results in generation of mitochondrial-derived metabolic stimulussecretion coupling factors (such as glutamate, citrate, NADPH and mitochondrially derived ROS) and promotion of insulin secretion (Fig