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A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

Bien, T., Bessler, S., Dreisewerd, K

Absorption and Bioavailability Kalaras, M.D., Richie, J.P., Calcagnotto, A

Ethics statement The animal study was reviewed and approved by Naval Medical University Animal Welfare and Ethics Committee