In rare situations, B12 shots itching rash anaphylaxis, a life threatening condition that can cause a fast heartbeat and difficulty breathing Other side effects that can occur include: shortness of breath, fast weight gain, and swelling congestive heart failure, the inability of the heart to adequately pump blood pulmonary edema, the buildup of fluid in the lungs peripheral vascular thrombosis, the obstruction of a vein with a blood clot hypokalemia, low potassium levels that can cause irregular heartbeats and muscle weakness fever tingling, numbness, and joint pain swollen tongue polycythemia, an increase in the red blood cell mass Additionally, B12 B12 shots are not necessary for weight loss
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The study was designed as proof of concept for NNMT as a drug-development target
Additionally, analogues containing the quinolinium scaffold lacked inhibitory activity against enzymes in the NAD + salvage pathway that bind nicotinamide-containing substrate, including NAMPT[27, 32] and the NAD + -dependent SIRT1 enzyme, which deacetylates NAD + to produce NA, a product inhibitor of SIRT1.[33] These results suggest that quinolinium-based NNMT inhibitors achieve selectivity by specifically interacting with the NA-binding pocket of NNMT,[17] unlike several known non-selective methyltransferase inhibitors that interact with the SAM-binding pocket, which is highly conserved among SAM-dependent methyltransferases.[34, 35] Membrane-permeable NNMT inhibitors reduced intracellular 1-MNA levels in a concentration-dependent manner and at pharmacologically relevant concentrations that did not impact cell viability, suggesting these small molecules interact directly with NNMT in cells
You can ask your doctor to do a blood test if you're worried you may have a vitamin B12 deficiency.
Alsuwaidan A, Pirruccello E, Jaso J, Koduru P, Garcia R, Krueger J, et al
