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In addition, serum levels of the acid-labile subunit (ALS) and IGFBP-3 are important in maintaining circulating IGF-I (Ohlsson et al., Igfals knock-out mouse model (Ueki et al., 2000) and by Domen et al

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The ribosomes present on the rough ER participate in synthesis of TGF- and then, other processes including eliminating N -terminal signal peptide, protein folding and glycosylation occur in their route of ER into Golgi apparatus (Manning et al., 2002

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Funding This study was supported by the National Natural Science Foundation of China to QZ (No.32270407) and the open fund of State Key Laboratory of Southwestern Chinese Medicine Resources (No.SCMR202103) and Natural Science Foundation of Sichuan (No.2022NSFSC0583) to JL

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