Villalobos-Labra R, Liu R, Spaans F, Sez T, Quon A, Wong M et al (2022) Placenta-derived extracellular vesicles from preeclamptic and healthy pregnancies impair ex vivo vascular endothelial function
The Hg 0 vapor was introduced into the reactor by N 2 (0.3 L min 1 )
Moreover, although the in vivo dose of LP-EVs in our study was chosen based on in vitro efficacy, experimental feasibility, and precedent from the literatures, the lack of comprehensive pharmacokinetic and biodistribution data following topical administration prevents a precise delineation of their spatiotemporal distribution, retention time, and clearance pathways in vivo, thereby limiting a deeper, quantitative understanding of the relationship between tissue exposure levels and therapeutic efficacy
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