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However, given the ubiquitous distribution of vitamin E, deficiency is difficult to achieve in animals and very rare in patients

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However, certain molecules, such as erastin and sulfasalazine can inhibit system XC and cause the depletion of cellular cysteine, leading to the impairment of the intracellular GSH homeostasis and ultimately, intracellular GSH deficiency and ferroptosis (44,45)

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doi: 10.1371/journal.pbio.2006203 53 ShuiSZhaoZWangHConradMLiuG

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