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Ingesting smaller amounts of nicotine or abstaining from nicotine entirely can cause symptoms of withdrawal

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Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems: Guidance for Industry (US Department of Health and Human Services, 2019)

And the FDA assured it wouldnt have to deal with a mountain of PMTAs for hardware by demanding that all components and parts applications would have to show how each device might work with any other component it could be combined with

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