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It significantly induced DNA strand breaks in HepG2 cells with hamster S9-mix only, with a mfc of 3.9 at 0.25 mM

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However, new targets from detailed molecular mechanistic analyses and improved gene therapy delivery technologies, such as using non-viral, nanoparticle-based DNA delivery mentioned below, provide renewed optimism

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We previously clarified that the excretion of uremic toxins in the SLCO4C1 transgenic rat model reduced hypertension, cardiomegaly, and inflammation in the setting of renal failure 6

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