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In a recent 12-week, randomized, placebo-controlled trial in untreated hypertensive subjects, daily intake of aged garlic extract (1.2 g of which contained 1.2 mg of S-allyl-L-cysteine [SAC]) was shown to significantly lower SBP by 11 mm Hg and DBP by 6 mm Hg on average in 50%-60% of participants, but reductions in blood pressure were not reported in 40%-50% of participants compared to placebo (110)

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Unlike pepsin, a well-known gastric Asp protease that cannot break down these Pro-rich gluten peptides, RmuAP1CD appears to tolerate Pro residues near the scissile bonds, the specific peptide bonds targeted and cleaved by proteases (Ali et al

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PGC1A is a transcriptional coactivator that plays a central role in the expression of genes acting against oxidative stress in combination with FOXO3A 29