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3A and B, respectively

Common side effects include nausea, constipation, and fatigue, particularly during dose escalation

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In the other hand alarmins release, including IL-33, IL-25 (also known as IL-17E), and thymic stroma lymphopoietin (TSLP), may activate type 2 innate lymphoid cells (ILC2), which participate to Th2-like T cell responses and enhance the production of IL-4 and IL-13 which directly and indirectly participate to enhanced ECM deposition

Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo