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In Ca9-22 cells, pre-treatment with all anticancer agents resulted in superior findings than pre-treatment with AGE followed by each anticancer agent in addition to the simultaneous treatment with AGE and each anticancer agent, but AGE also improved the inhibitory effects following simultaneous treatment with 5-FU (Fig

Three pilot studies with very small sample sizes, a Phase II trial whose results remain unpublished, and a regulatory record that reflects the FDA's own assessment that sufficient human safety data do not exist that is the complete ledger as of 2025