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In agreement with their single-drug effects, both (M+D)/2 and (M+D+V)/3 downregulated proteins linked to mitochondrial ATP synthesis and cell cycle ( Supplementary Figures S5 , S6

Preserve methyl donors (SAM) less NNMT activity means a better SAM:SAH balance, which can steady epigenetic gene regulation

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Every time a cell divides, it needs to copy its DNA accurately

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