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2.5 Dosing for Induction of Spermatogenesis in Males with Azoospermia and Primary or Secondary Hypogonadotropic Hypogonadism: Prior to initiation of treatment with GONAL-f: Confirm azoospermia Perform a thorough medical and endocrinologic evaluation to exclude other treatable etiologies of azoospermia Confirm hypogonadotropic hypogonadism Exclude primary testicular failure Normalize serum testosterone levels The dosing scheme follows a stepwise approach and is individualized for each man

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While unlikely with a short insulin needle used for subcutaneous injections, accidentally hitting a vein would lead to a very rapid, intravenous-like administration

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Chemokine stromal cellderived factor 1 induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals