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The study demonstrated that cynaroside exhibited no significant toxic side effects while improving glucose-lipid metabolism disorders in obese mice, reducing inflammatory responses, enhancing gut microbiota diversity, and stabilizing the intestinal microbial balance (Yang et al., 2025)

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Upon injury, the injured nerves quickly undergo Wallerian degeneration characterized by dedifferentiation of mature Schwann cells into a repair phenotype with increased phagocytic, migratory, and secretory functions, followed by the recruitment of macrophages to aid the clearance of axonal and myelin debris [2, 4, 5]