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In addition, this pathway indirectly modulates responses to immunotherapy by remodeling the tumor microenvironment, promoting infiltration of tumor-associated macrophages and upregulating immune checkpoint molecules such as PD-L1) (275)

40 SUCNR1 expression is upregulated in human SDH-mutated tumors and in various prevalent cancers

The enzyme AGAT utilizes L-Arg and Gly to produce guanidinoacetate, which is further metabolized to form creatine

Ravi Salgia is supported by NIH/National Cancer Institute-R01 award (R01 CA100750 and CA109640), American Cancer Society Award (National), American Lung Association, and Institutional Cancer Research awards from the University of Chicago Cancer Center (with the American Cancer Society) and the V-Foundation (with Geelard Family)