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In this study, Nociceptive behavior was quantitatively evaluated using cold allodynia and thermal hyperalgesia assays, histopathological changes in the dorsal horn of the spinal cord were examined using H&E staining, and oxidative stress factors (MDA, SOD, GPX, TAC), inflammation markers (IL1B, TNF-), and liver enzymes (ALT, AST) were measured

Additional information Ethics Approval And Consent To Participate This study adhered to all relevant ethical regulations and was approved by the Medical Ethics Committee of the Hospital of Stomatology, Sun Yat-Sen University (Seal) (KQEC-202343-01)

K.SalacinskiH

doi: 10.1158/0008-5472.CAN-15-1208 101 ZhaoXLiYWuH

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Unlike natural GHRH, CJC-1295 is modified with Drug Affinity Complex (DAC) technology, which significantly extends its half-life allowing for sustained GH release over the course of a week with fewer injections