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Modification of Cys-72 and Cys-338 either by their crosslinking 33 or by oxidized glutathione inhibits catalytic activity 34 through long range communication with the active site ~25 distant

Nina Kim, MD, MSc Associate Editor Professor of Medicine Division of Allergy & Infectious Diseases University of Washington Disclosures : None Reviewer: David H

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While medications can slow progression and dialysis can replace filtration, the medical field has long lacked an approach that helps the kidneys actually repair themselves

doi: 10.1083/jcb.200203084 98 PanQKleerCGvan GolenKLIraniJBottemaKMBiasCet al

All raw data, including search engine output has been deposited to PRIDE with the dataset identifier PXD061610